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Can I take Clonazapam and Benadryl together?

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Taking Clonazepam and Benadryl (diphenhydramine) together can cause an additive or synergistic increase in central nervous system and/or respiratory depressant effects. This is listed as a moderate interaction and I would definitely not recommend taking these together unless you have been directed to do so by a health professional. Any comments?

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Currently there are "8 comments" on this Question:

  1. Shantell says:

    Sep 10, 2006 Hell, take too many Benadryl and you can die! However, I sometimes take diphen and Klonopin together (1-2 mg of k-pin). I don’t do it often,

  2. Lanora says:

    Can I use Benadryl Itch Stopping my feet (about 100 between both feet a Gel and Benadryl Allergy Oral? I have an insane amount Tablets at the same time of flea bites mostly on

  3. Chery says:

    You might need a nap.  But Wellbutrin tends to increase energy while Benadryl causes drowsiness, so they might cancel each other out.  As a Wellbutrin user, I find that taking a 24 hour allergy medication before bed is sufficient. More:http://wiki.answers.com/Q/What_happens_if_you_take_Benadryl_and_Wellbutrin_together

  4. Reginia says:

    Nothing adverse… Tylenol PM is Tylenol and Benadryl together. More:http://wiki.answers.com/Q/What_happens_when_you_take_Tylenol_and_Benadryl_together

  5. Vonnie says:

    It makes you so stupid that you forget how to spell "meth". More:http://wiki.answers.com/Q/What_happen_mixing_together_benadryl_and_smoking_crystal_math_drug

  6. Joann says:

    Can I take Benadryl (diphenhydramine), a short-acting

  7. Jenniffer says:

    Like Benadryl, the drug blocks histamines, although Vistaril does so at a much Patients who take this antihistamine also experienced feelings of sedation and As with all medications, however, the patient can develop a tolerance to the Detail:http://www.ehow.com/about_5113874_medicine-25-mg-used-for_.html

  8. Chris says:

    Interesting. I am on 2mg of Clonzzapam per day. I take at at night. I also take 25mg of benadryl (diphenhydramine) and have done so for over a year. I have no issues what so ever. I checked with my Doctor and my pharmacists and neither mentioned any serious side effects. I have had none. I have also taken Bendadryl doing the day , generally 25 to 50mg, again no issues. The half life of Benadryl is much shorter than Clonzapam. The peak of Benadryl is faster, so I take about 2 hours later than the Clonzapam. Why am I on such a mixture? I have Sleep disorder, Panic disorder and Menieres disease. I am also taking all this in combination with Lexapro and Maxide. . I guess situations and opinions vary , but I would ask a doctor if its really a worry. I always call my pharmacists and ask. Better yet talk to your doctor about why you think you need to take the medication in the first place.

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