Currently there are "8 comments" on this Question:

  1. Ileana says:

    Benadryl, or diphenhydramine hydrochloride, when taken by mouth, works within 15 to 60 minutes. When injected through a muscle, it takes 20 to 30 minutes to

  2. Cassey says:

    Benadryl can take anywhere from 15-60 minutes to kick in for adults, depending on all sorts of factors like your metabolism, age, body weight etc. If you are a 5 foot tall, 100 lb girl you might be around the 15 minute side. If you are a 64 250 lb guy, obviously it would take longer. You should monitor yourself and find out how long it takes for you personally, so you know for the future.

  3. Joane says:

    how long before it takes benadryl to kick in? about an hour ago I and I still dont feel took 50 mg of benadryl tired at all! I’m wide awake. About how long does it usually tak

  4. Michell says:

    Dogs are allowed to have Benadryl but it’s used for reactions from insect bites etc, itchy stuff. It won’t do anything for the rash. You’ll just have to keep him comfortable. Rinse the area off with water, as there may still be residue on t… More:http://answers.yahoo.com/question/index?qid=20080710193619AAjNuY4

  5. Mardell says:

    Benadryl can take anywhere from 1 to 3 hours to make a person start to feel drowsy, though it is best to be at home or someplace where you will be sleeping before taking it. More:http://www.chacha.com/question/how-long-does-it-take-for-benadryl-2-kick-in-and-make-you-tired

  6. Luis says:

    It should take around 30 minutes for the effects of Benadryl Allergy medicine to take effect! More:http://www.chacha.com/question/how-long-does-it-take-for-benadryl-allergy-tablets-to-kick-in

  7. Leonora says:

    It depends on the person but it can take from around 45 minutes and up.

  8. Carolee says:

    Long-Term Effects of Tylenol PM; How Tylenol Works. Print this Diphenhydramine is sold under the brand name Benadryl and Like most systems in the body, the muscular system does not work in isolation. How to Take Tylenol & Aleve Detail:http://www.ehow.com/how-does_4926089_tylenol-pm-work.html

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